Tirzepatide is the latest once a week injection that can help you minimize food cravings and lose weight.

Tirzepatide—like semaglutide—works with glucagon-like peptide-1 (GLP-1), a hunger and appetite hormone, to create an increased feeling of fullness. However, unlike semaglutide, it is not a GLP-1 agonist and also works with glucose-dependent insulinotropic polypeptide (GIP). As a GIP analog, tirzepatide activates both the GLP-1 and GIP receptors.

At Well Medical Arts we offer the compounded version of Tirzepatide that is also sold under the brand names of Mounjaro and Zepbound. Our Tirzepatide comes from a state of the art compounding pharmacy that is both 503A and 503B compliant.

What is the difference between Semaglutide and Trizepatide?

Although both tirzepatide and semaglutide are used to assist patients with type 2 diabetes and obesity in losing weight and improving cardiovascular diseases, there are some significant distinctions between them.

The main distinctions between these drugs are that they’re two different classes of drugs and have slightly differing targets in the brain.

Tirzepatide is unique in its class of medications since it targets both the GIP and GLP-1 receptor agonists. By activating these receptors, tirzepatide functions differently from semaglutide.

Semaglutide exclusively targets the GLP-1 receptor agonist. However, it has been on the market longer than tirzepatide and is supported by greater research and clinical proof.

Can I switch from Semaglutide to Tirzepatide?

Because semaglutide and tirzepatide work in different ways and cause different side effects, people’s health should be carefully looked at before transitioning. Both medicines can help with diabetes and obesity, but tirzepatide may help people lose more weight and have better metabolic effects because it works on two different receptors.¹ To make sure the patient is safe and happy, though, expectations and side effects must be carefully managed, especially those affecting the digestive system.

Tirzepatide and Semaglutide effects on birth control.

Both tirzepatide and semaglutide can reduce the effectiveness of oral contraceptives. It is recommended that prior to starting either medication you consider switching to a contraceptive other than “the pill”. It is also recommended to NOT become pregnant while using either medications.

Is Tirzepatide more effective than Semaglutide?

Some research shows tirzepatide might be slightly more effective for weight loss, both drugs, when combined with lifestyle changes, may help people manage their weight and glycemic control. Overall efficacy depends on adherence to treatment and individual factors.  Both tirzepatide and semaglutide are effective medications for weight loss. Each person’s body will respond differently to various medications. Therefore, tirzepatide will work for some while others may find more benefits from semaglutide.

What are the potential side effects from Semaglutide and Tirzepatide?

Both Tirzepatide and Semaglutide may have potential side effects. These side effects may be mild to severe. Tirzepatide (Mounjaro and Zepbound) may cause nausea, vomiting, diarrhea, constipation, indigestion, and stomach discomfort.

Tirzepatide may have severe side effects but may be rare, which may include:

• Hypoglycemia
• Pancreatitis
• Kidney failure
• Allergic reactions
• Vision changes
• Gastrointestinal issues
• Vision changes
• Stomach pain

Who can NOT take Tirzepatide?

• You have a personal or family history of medullary thyroid carcinoma (Thyroid Cancer)
• Multiple Endocrine Neoplasia syndrome type 2
• You are pregnant or plan to become pregnant while taking this medicine
• You are diabetic and/or taking any medications related to lowering your blood sugar levels without speaking with your endocrinologist. Specifically, if you are prescribed Insulin because the combination may increase your risk of hypoglycemia (low blood sugar) and dosage adjustments by your provider may be necessary.
• You have a history of Pancreatitis
• You are allergic to BPC-157, Semaglutide, Tirzepatide or any other GLP-1 agonist such as: Adlyxin®, Byetta®, Bydureon®, Ozempic®, Rybelsus®, Trulicity®, Victoza®, Wegovy® Monjauro or Zepbound.
• If you have other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor/pharmacist your medical history .
• Kidney disease. Stomach or intestine problems. Thyroid cancer or if someone in your family had thyroid cancer. An unusual or allergic reaction to tirzepatide, other medications, foods, dyes, or preservatives.

Possible drug interactions with Tirzepatide.

• Semaglutide and Tirzepatide can make oral contraceptive less effective. It is recommended that if you are considering starting either of these medications you use an alternative form of contraception and it is recommended to NOT get pregnant on these medications.
• Any blood thinning medications (warfarin) can be affected, it can slow the absorbtion of the medication. It is not recommended to use Semaglutide or Tirzepatide if you are taking blood thinning medications.
• Any Anti-diabetic agents, specifically: Insulin and Sulfonylureas (e.g., g lyburide, glipizide, gl imepiride, tolbutamide) due to the increased risk of hypoglycemia (low blood sugar).
• Do not take with other GLP-1 agonist medicines such as: Adlyxin®, Byetta®, Bydureon®, Ozempic®, Rybelsus®, Trulicity®, Victoza®, Wegovy® (THIS IS NOT AN ALL-INCLUSIVE LIST).
• Other medications used in diabetes, please tell your provider about any medications that may lower your blood sugar.